国立国際医療研究センター研究所 生体恒常性プロジェクト

英文原著論文(NCGM着任前)

  • Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, *Suda T. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

    Genes Dev 2008 Apr 15;22(8):986-991.
  • *Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, :Suda T. Stem Cell Defects in ATM-deficient Undifferentiated Spermatogonia through DNA Damage-induced Cell Cycle Arrest.

    Cell Stem Cell 2008 Feb; 2(2):170-182.
  • #Kubota Y, #Takubo K (#equal contribution), Suda T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche.

    Biochem Biophys Res Commun. 2008 Feb 8;366(2):335-339.
  • Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, *Suda T. Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche.

    Cell Stem Cell 2007 Dec; 1(6):685-697.
  • Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y, *Suda T. Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.

    J Exp Med. 2007 Jul 9;204(7):1613-1623.
  • Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, *Suda T, *Hirao A. Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool.

    Cell Stem Cell 2007 Jun; 1(1):101-112.
  • Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, *Ikeda E. Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.

    Am J Pathol. 2007 Apr;170(4):1389-1397.
  • Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, *Hirao A. Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

    J Immunol. 2007 Jan 1;178(1):103-110.
  • *Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T. Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.

    Biochem Biophys Res Commun. 2006 Dec 29;351(4):993-998.
  • Ito K, *Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, *Suda T. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.

    Nat Med. 2006 Apr;12(4):446-51.